physician global assessment sle

et al. Genetic linkage has related dysfunction of . In 89 studies [2, 3, 913, 21102] the PGA was used to measure disease activity as a whole, therefore satisfying the content validity criteria. An official website of the United States government. All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients' age. , Perneger T , Cella D. van Vollenhoven RF Medizinische Universitt Graz Austria/sterreich - Forschungsportal - Medical University of Graz Direkt zur Navigaton springen . In most studies, the PGA was assessed by a rheumatologist experienced in SLE care or research and, as already stated, the ICC reliability was different for an untrained physician and a trained investigator [36]. , Shinada S It estimates how similar a given patients scores were at the two visits. Patient-reported outcomes (PROs) reflect the patient's perspective and are used in rheumatoid arthritis (RA) routine clinical practice. , Gallacher AE Frontiers | Cutaneous lupus erythematosus disease assessment , ODell JR Flow chart illustrating the literature search and study selection. , Sadovici-Bobeica V et al. Physician global assessment in systemic lupus erythematosus: Can we Methods . , Jolly M. Ribi C , Annapureddy N , Engel SM , McGwin G PGA; disease activity; physician global assessment; psychometrics; systemic lupus erythematosus. Intoduction to X 20 - Physician Global Assessment Liang et al. Ann Rheum Dis 2011;70:54-9. . PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. Arriens C 2014 Dec;53(12):2175-81. doi: 10.1093/rheumatology/keu153. Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease that can occur with or without systemic lupus erythematosus (SLE). A PGA 2 correlated with a risk of pregnancy loss (29% vs 8%, P=0.005) [49]. Improving patient pathways for systemic lupus erythematosus: a multistakeholder pathway optimisation study. , Floris A Accessibility This button displays the currently selected search type. , Mikolaitis-Preuss RA , Klein-Gitelman MS Five studies have demonstrated good ICC values for reliability (all >0.60 and ranging up to 0.97). , Kalunian K Immune Disorders, Deficiency, Etc - Key Points to Review: Initiation of , Magder LS Lai J-S et al. Karol DE , Urowitz MB. Akhter E Thanks to this feature, the PGA was included in composite indices with the aim of rating manifestations not included in glossary-based instruments such as the SLEDAI and BILAG [3] or for which a threshold has been defined (cytopenia). The Physician Global Assessment (PGA) of treatment response measures the overall response to treatment as assessed by the physician. et al. The Physician's Global Assessment (PhGA) is a number without unit. HHS Vulnerability Disclosure, Help Because of its dynamic nature, this disease has an unpredictable natural course leading to high . Careers. Measurement properties of the PGA were analysed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) terminology [19]. Gandhi N The pooled correlation coefficient (95% CI) is given both for the fixed effects model and the random effects model. et al. Cloud, mobility, security, and more. , Urowitz MB. et al. The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate the intracellular signaling of cytokines in a wide spectrum of cellular processes. Use of Physician Global Assessment (PGA) in Systemic lupus - medRxiv However, it was used as a single outcome measure only in two studies [49, 100], while in the majority the PGA was scored together with another instrument (typically the SLEDAI) [2, 9, 11, 12, 21, 24, 30, 32, 34, 3740, 44, 45, 48, 49, 55, 58, 59, 61, 63, 64, 66, 67, 74, 75, 80, 82, 86, 8995, 103]. The SRI is a validated SLE disease activity instrument used to detect clinically meaningful improvement of disease in SLE clinical trials. , Su J Clinical composite measures of disease activity and damage used to evaluate patients with systemic lupus erythematosus: A systematic literature review. . An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. Physician Global Assessment International Standardisation COnsensus in , Mosca M The SRI is a composite instrument comprised of the SELENA-SLE Disease Activity Index [SELENA-SLEDAI], Physician Global Assessment (PGA) and British Isles Lupus Assessment Group (BILAG) 2004. CLOSED ANGLE/ ANGLE CLOSURE GLAUCOMA. , Wetter J Elevation of erythrocyte sedimentation rate is associated with disease activity and damage accrual, The systemic lupus activity measure-revised, the Mexican systemic lupus erythematosus disease activity index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus, Small changes in outpatients lupus activity are better detected by clinical instruments than by laboratory tests, Development and initial validation of the systemic lupus erythematosus disease activity index 2000 responder index 50, Sensitivity to change of 3 systemic lupus erythematosus disease activity indices: international validation, Systemic Lupus Erythematosus Disease Activity Index 2000 Responder Index 50: sensitivity to response at 6 and 12 months, Validation of the functional assessment of chronic illness therapy-fatigue scale in patients with moderately to severely active systemic lupus erythematosus, participating in a clinical trial, Psychological distress and changes in the activity of systemic lupus erythematosus, The rating scale preference measure as an evaluative measure in systemic lupus erythematosus, Comparison of the validity and sensitivity to change of 5 activity indices in systemic lupus erythematosus, Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months, Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus, Epratuzumab for patients with moderate to severe flaring SLE: health-related quality of life outcomes and corticosteroid use in the randomized controlled ALLEVIATE trials and extension study SL0006, Measuring systemic lupus erythematosus activity during pregnancy: validation of the lupus activity index in pregnancy scale, Autoantibodies against albumin in patients with systemic lupus erythematosus, Association of depression with socioeconomic status, anticardiolipin antibodies, and organ damage in patients with systemic lupus erythematosus: results from the KORNET registry, Placebo-controlled randomized clinical trial of fish oils impact on fatigue, quality of life, and disease activity in systemic lupus erythematosus, Serum free light chains, interferon-alpha, and interleukins in systemic lupus erythematosus, Vitamin D levels in Chinese patients with systemic lupus erythematosus: relationship with disease activity, vascular risk factors and atherosclerosis, Systemic lupus erythematosus disease activity index 2000 responder index-50: a reliable index for measuring improvement in disease activity, Testosterone patches in the management of patients with mild/moderate systemic lupus erythematosus, Turkish LupusPRO: cross-cultural validation study for lupus, Cross-cultural validation of a disease-specific patient-reported outcome measure for lupus in Philippines, Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial, Sensitivity and specificity of plasma and urine complement split products as indicators of lupus disease activity, The TNF locus is altered in monocytes from patients with systemic lupus erythematosus, Effect of pregnancy on disease flares in patients with systemic lupus erythematosus, Frequency of lupus flare in pregnancy: the Hopkins Lupus Pregnancy Center experience, Morbidity of systemic lupus erythematosus: role of race and socioeconomic status, Classification and definition of major flares in SLE clinical trials, Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study, COSMIN guideline for systematic reviews of patient-reported outcome measures, Validity and reliability in social science research, Understanding the minimum clinically important difference: a review of concepts and methods, Statistical significant change versus relevant or important change in (quasi) experimental design: some conceptual and methodological problems in estimating magnitude of intervention-related change in health services research, Minimum important difference between patients with rheumatoid arthritis: the patients perspective, Responsiveness and sensitivity to change of SLE disease activity measures, The Author(s) 2020. Copay AG Criterion validity is defined as the degree to which the scores of an instrument adequately reflect the truth in the form of a gold standard [107]. The quantification of reliability is expressed by a correlation coefficient. JSS Medical Research. ATI Comprehensive Predictor Exam 2019 (180 Q & A, Verified and 100 Impact of anti-SARS-CoV-2 antibodies of different isotypes (IgA, IgG, IgM) on attainment of PGA . et al. The results are similar, and less than half the time is required for scoring. , Sengupta M , Hochberg M. Touma Z , Magder LS To determine longitudinal associations between Physician Global Assessment (PGA) and patient-reported outcomes (PROs) in patients with systemic lupus erythematosus (SLE). Enocsson H Vil LM Face validity is satisfied when the instrument is considered able to capture what it should capture (i.e. Eudy AM Trusted for over 30 years to provide and transform technology into complete solutions that advance the value of IT. 2022 May;9(1):e000700. et al. This suggests that the role of the PGA is limited for disease activity assessment when used as a single instrument. The aim of this systematic review is to describe and analyse the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. RN-BSN HOLISTIC HEALTH ASSESSMENT ACROSS THE LIFESPAN (NURS 3315) Sociology of Social Problems (SOC213) , Socher SA , Sjwall C In the last 30years, more than a dozen scores have been derived to assess disease activity in SLE, but not all of these have proven to be valid and reliable tools. Funding: The study was funded through the training Bursary Programme 2019 of the SLEuro European Lupus Society. Brunner HI While specific studies remain to be performed to determine the optimal method for scoring the PGA, this literature search showed that the most adopted form of PGA was a 10cm 03 VAS with anchors (0, none; 1, mild; 2, moderate; 3, severe activity) [3]. It should be noted that the PGA correlates with several other instruments that measure disease activity. Montreal, Canada Area. Annapureddy N . Physician's Global Assessment Scale (PGA) or Investigator's Global Assessment Scale (IGA) measures disease status in a broad range of diseases. , Hambleton IR Data regarding divergent validity are lacking for the PGA. 'Not at target': prevalence and consequences of inadequate disease control in systemic lupus erythematosus-a multinational observational cohort study. 2022 Mar 14;24(1):70. doi: 10.1186/s13075-022-02756-3. Scoring systemic lupus erythematosus (SLE) disease activity with simple Methods This SLR was conducted by two independent reviewers in accordance with the PRISMA statement. Epub 2014 Jul 10. Construct validity is shown by the good correlation observed with the SLEDAI, BILAG, SLAM, LAI and ECLAM [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. Franklyn K PMC The PGA intraRR was assessed in three studies [10, 68, 94] and ranged from 0.55 [68] to 0.88 [10]. http://oml.eular.org/glossary (31 January. Comparison of the validity and sensitivity to change of 5 activity indices in systemic lupus erythematosus. , Landis RC , Fortin PR , Costenbader K How does one assess and monitor patients with systemic lupus et al. , Kraag GR BATCH RUBY INTENSIVE REVIEWRTRMF 3. [9] for a disease activity index scored on a VAS ranging from 0 to 3, with an increase of 1.0 since the last visit indicating a flare. Prinsen CAC Touma Z Devilliers H Thus the development of a comprehensive index for assessing disease activity still represents one of the most important challenges in SLE [7]. We analysed the performance of the SELENA SLEDAI Physician's Global Assessment (SSPGA) and the Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL) as measures . , Garabajiu M The Senior Lead will be responsible for: Managing end to end production, governance and controls of Derivatives Standardized and Advanced RWA, and SLE Actuals. Compared with nonresponders, BICLA responders had greater improvements in global and organ-specific disease activity (Physician's Global Assessment, SLE Disease Activity Index 2000, Cutaneous Lupus Erythematosus Disease Area and Severity Index Activity, and joint counts; all nominal P < 0.001). Objective: To examine the feasibility of using Physician Global Assessment (PGA) scores to collect and track patient acne and . According to the authors, this difference was probably due to the greater familiarity of the physicians with the BILAG-2004 index. SLE has protean and often complex manifestations, necessitating careful clinical assessment. , Glassman DS Background: Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity.